Functional Specifications: 1. The proton therapy system must be able to receive treatment plans, conforming to the latest version of DICOM-RT-Ion, developed by a proton PBS treatment planning system (TPS) via oncology information system (OIS). 2. The proton therapy system must be able to perform 2D and 3D image guidance to set up patients, deliver intensity-modulated proton therapy (IMPT) treatments, and send images, spatial registration objects, and treatment records back to OIS. a. The imaging system must include patient localization using orthogonal and volumetric imaging. b. Patient imaging and localization shall include 3DOF and 6DOF for orthogonal and volumetric imaging. 3. The proton therapy system must be able to treat all disease sites in radiation oncology, including target volumes in the head and neck, central nerve system, thorax, abdomen, pelvis, and extremities. 4. The delivery system must support respiratory motion management, including support for third-party gating signals. 5. All required sub-systems, including imaging guidance and gating, should be fully integrated with the proton therapy system. 6. The proton therapy system should be able to treat patients for up to 20 hours/day. 7. The useful life of the proton therapy system should operate for a minimum of 15 years. Technical Specifications: 1. The proton therapy system must be able to provide proton beams with penetrations in water ranging from 4 cm to 32 cm. 2. The proton therapy system must support a 4 cm range shifter. 3. The proton therapy system must support a ridge filter if it is synchrotron-based. 4. Proton pencil beams must have in-air spot sizes at isocenter (sigma) less than: a. 8 mm for 70 MeV, 5.5 mm for 100 MeV, 3.5 mm for 150 MeV, and 3 mm for 200 MeV and greater...
