The purpose of this RFA is to fund eligible organizations to implement evidence‐based, high‐impact strategies to address the opioid overdose epidemic in Rockingham County, North Carolina. In addition, this RFA builds capacity and local infrastructure to respond to the overdose crisis in Rockingham County, North Carolina. The goals of the RFA are to: 1. Enhance community efforts to develop and/or expand evidence‐based programs and resources to address opioid use disorder. 2. Build capacity and infrastructure to measure the impact of programs and prevent fatal and non‐ fatal overdoses in Rockingham County. 3. Reduce overdose deaths and emergency department visits in Rockingham County. 4. Strengthen community partnerships to improve access to care related to opioid use disorder.