Specifications include, but are not limited to: • Measurement angle: at least 3 angles: Back scatter angle (~170°+/-5), right angle (90°), and forward scatter angle (~15°+/-5). • Must be able to measure a minimum diameter of at least 0.3 nm and a maximum diameter of at least10 μm. • Must have a minimum sample volume of at least 12 μL. • Must have a minimum sample concentration sensitivity of 0.2 mg/mL 15 kDa Protein. • Must have a minimum temperature of at least 0°C and a maximum temperature of at least 120°C. Temperature control must be in intervals of at least 1°C. • Must be capable to measure absolute particle concentration. • Must have titration capabilities with automatic degassing of at least 3 titrants. • Must have selectable narrow band filter to allow signal improvement of fluorescent samples, in backscatter mode. • Must have selectable polarization detection parallel to input laser polarization, in backscatter mode. • Must have selectable polarization detection perpendicular to input laser polarization, in backscatter