Specifications include, but are not limited to: The work to be performed will be at the UNMC Durham Research Centers 1 and 2 facilities (DRC1 and DRC2) located at South 45th Street and Dewey Avenue in Omaha. Spread between DRC1 and DRC2 facilities contain research laboratories, tissue culture rooms, instrument rooms, walk-in cold rooms, freezer rooms, dark rooms, imaging rooms and 2 Biosafety Level 3 laboratory (BSL-3) and Animal Biosafety Level 3 laboratory suites (ABSL-3). The project will improve biocontainment infrastructure within key biocontainment research facilities in a way that increases capacity to conduct research on highconsequence pathogens, maximizes synergy between the various biocontainment laboratories and increases biosecurity. Upgrades in the modern technologies needed in the BSL-3 and ABSL-3 laboratories to conduct cutting-edge studies on new and emerging pathogens and to address critical questions related to disease pathogenesis.