Specifications include, but are not limited to: 2.2. Tandem Quadrupole Analyzer 2.2.1. Two high-resolution high-stability quadrupole analyzers (MS1, MS2), plus prefilters 2.2.2. Mass Range of 2-1250 amu, to allow for an analysis of a wide range of compounds. 2.2.3. Use of Collision cell technology to block meta stable helium ions and neutral molecules reducing baseline noise. 2.2.4. Electron impact (EI) and chemical ionization (CI) modes of ionization. 2.2.5. Acquisition Modes: 2.2.5.1. Full Scan 2.2.5.2. MS Product Ion Scan 2.2.5.3. Precursor Ion Scan 2.2.5.4. Selected Ion Recording (SIR) 2.2.5.5. Multiple Reaction Monitoring (MRM) 2.2.5.6. Simultaneous Full Scan and MRM (RADAR) 2.2.6 Must be able to switch between MS (full scan) and MS/MS acquisition modes in 3 milliseconds without compromising data quality in either mode. Collision gas pressure must be maintained at an optimal constant value for both MS and MS/MS acquisition modes. 2.2.7 Rapid multi-component MRM data acquisition without loss in signal intensity, while minimizing cross talk between adjacent MRM channels. 2.2.7.1 At an MRM acquisition rate of 500 MRM data points per second there should be no more than 20% loss in signal compared to 50 MRM data points per second. 2.2.8 The detector should operate in both positive and negative ion modes, and able to switch rapidly between the two modes (< 16 milliseconds). 2.2.9 Should include dual EI yttrium coated long lasting filaments in the source. In the event of a filament failure, the second filament could be used immediately, preventing data loss for that acquisition. The filaments must have an automated filament shut-off linked to pressure readbacks to avoid filament burn-out. 2.3 Gas Chromatograph – Agilent 8890 with the following components 2.3.1Injector with a Programmable temperature Vaporizer (PTV) inlet 2.3.2 Flame Ionization Detector (FID) 2.3.3 Oven temperature – Ambient +4 to 450 °C, with 20 oven ramps and plateaus. Heating Ramp Rate -75 °C/min (120V) 2.3.4 A CTC PAL 3 autosampler capable of liquid injection, headspace and SPME analysis. 2.4 System Software Capabilities 2.4.1 The system must have intelligent software to automatically perform source tuning, mass resolution, calibration from a reference compound. In addition, the software must provide multiple system checks for temperatures, filament settings, peak shapes, peak resolutions, peak positions, peak ratios and instrument vacuum. Provide notifications when issues arise. 2.4.2 During a sample run, the intelligent software must be able to report in real time, QC samples, blanks and internal standards results. Automated decisions based on defined quality control criteria must allow the software to either continue or terminate the analysis thus preventing sample loss due to quality control samples being outside of defined limits. 2.4.3 Include a trending tool for plotting results from quantitative data sets. Allowing for inter and intra batch comparisons to be plotted for any calculated result in a sample set. 2.4.4 Capable of standard addition quantification
