Specifications include, but are not limited to: We require a triple quadrupole mass spectrometer (LC/MS/MS) to expand the analytical capabilities of our laboratory and provide us with the capability to quantify and identify compounds relevant to food safety and quality enhancement objectives. The following are our needs and specifications. The instrument required for this type of analysis is a triple quadrupole mass spectrometer (LC/MS/MS), specifically preferring one equipped with a QTRAP or Orbitrap or equivalent capability technology. The system should be complete with operation software and with the software and license for managing spectra library for structural identification and quantification. In order to meet our sensitivity requirements, the instrument must possess a true orthogonal source capable of switching quickly between both electrospray (ESI) and atmospheric pressure chemical ionization (APCI) modes without changing the source. The instrument must provide high sensitivity analysis over a wide range of flow rates with quick-change between APCI and the ESI probes. The instrument’s design should have a low likelihood that any non-charged ions will contaminate the vacuum section of the instrument. We need a source that can be removed from the host system without tools and can be replaced with a different one in less than one minute. We also require a source design that allows for cleaning without breaking vacuum. Due to the broad range of analytes we encounter we need to be able to use the widest possible range of LC flow rates, from 5uL/min to at least 3mL/min. The ion source should allow us to use the full range of HPLC columns including narrow bore, standard bore, and UHPLC columns.