Specifications include, but are not limited to: This opportunity will fund the infrastructure of TrialNet Clinical Centers to support active participation in the TrialNet scientific agenda as well as screening for and recruitment into trials and studies, trial conduct, retention, and follow-up. Limited funds will also be provided to Clinical Centers for their staff time and activities in support of Affiliate Sites, if well justified. All current and new Clinical Centers and Affiliate Sites will continue to be supported for screening and patient care costs through capitated payments from the TNCC. The funds to be awarded under this ITN are to support investigators’ time to participate in TrialNet scientific planning, publications, protocol development and implementation, leadership, affiliate oversight and efforts to enhance identification and enrollment through events that extend beyond a Center’s own practice or catchment area.