The primary goal of this study is to determine effective interventions that help improve the health and safety of transit workers. The objectives of this research are: Investigate and address the gaps highlighted in TCRP Research Report 217, with promising approaches, interventions, and strategies. Provide actionable, evidence-based recommendations and implementation frameworks that transit agencies and adjacent sectors have employed. Identify transit agencies and/or adjacent sectors that have tools to measure return on investment (ROI). If none, provide recommendations for tools or any other methods agencies use to measure the value added. Building on research findings from TCRP Research Report 217, TCRP Research Report 245, and the APTA Transit Workforce Shortage Report, this research will focus on innovative safety protocols, ergonomic improvements, mental health needs, and health programs specifically designed for transit work environments. By identifying and assessing these methods, the study seeks to provide actionable recommendations for transit agencies to enhance worker safety, improve health outcomes, and potentially lower associated costs.