The Massachusetts Health Policy Commission (HPC), in collaboration with the Department of Public Health (DPH) and on behalf of several state agencies working in cooperation (see Background for additional detail), is issuing this Request for Information (RFI) to obtain stakeholder input on “Moving Massachusetts Upstream” (MassUP), a coordinated state initiative to support partnerships between health care systems and community organizations to address the social determinants of health (SDoH). This RFI will inform the design of MassUP. Any organization or individual interested in the MassUP initiative (e.g., a community organization, health care provider, social service agency, local government body, etc.) is invited to submit a response to this RFI.